Intra-hepatic Cholestasis of Pregnancy (ICP) and Ayurveda - Dr. Nilofar Shaikh
Abstract: Intra hepatic cholestasis (ICP) is the second most common cause of jaundice in pregnancy. The stasis of bile with rise in conjugated bilirubin is probably due to excess circulating estrogen. Genetic, familial and abnormal progesterone metabolism have been observed. The manifestations of ICP usually appear in the last trimester. The onset is insidious and Pruritus is the primary clinical symptom of ICP. There may be weakness, nausea, slight jaundice or even vomiting are found with pruritus. There is rise in the levels of AST, ALT and serum alkaline phosphatase. There are increased risks of preterm labor, low birth weight babies, IUFD , meconium stained liquor and postpartum hemorrhage. The features of Intra hepatic cholestasis subside within two weeks postpartum. In ayurveda, treatment of Garbhini Kamala (Jaundice during pregnancy) is described in Kashyapa Samhita. The drugs who have Mridu pita virechaka (Mild laxative) and Raktashodhaka (Blood Purifiers) properties may help to reduce the symptoms of Intra hepatic cholestasis during last trimester.